Originally planned as the “best practices book”, the MAST Manual represents selected topics and the most valuable, condensed knowledge legacy from the MAST project, gathered between April 2018 and November 2020, on a journey through over 20 (intensive learning, “pop-up”, symposium, “Interfacing academy” etc.) events and over 60 meetings of the project group. Developing a curriculum for rethinking social values, if not completely re-imagining or even practically redesigning the future world, MAST involved over 30 artists, scientists, curators, innovators, activists from across creative and cultural industries, as well as technology and natural sciences, social sciences, and humanities. Another 50 students and alumni have experienced the manifold intensive workshops, symposia, festival events, exhibitions and critical round tables that reached out to over a thousand project- external stakeholders. Their feedback was translated into the criteria for the selection of contents for this Manual. Next to the backgrounds on teaching and research in the (seeming) paradox between Social Values and the science-based technological progress, the Manual presents the emerging graduate profile of an innovation catalyst into ample detail, and embeds it within the developed module syllabus. This profile is to facilitate the actual innovation process through the MAST curriculum that introduces art thinking as its key stage, before design thinking in the innovation cycle that is structured along ten key stages. The Manual can, but must not necessarily be read in linear form. For deeper reading on certain topics, the Manual in several of its parts links out to further documents and documentations (incl. ample video materials from symposia, round tables, lectures etc.) at the mastmodule.eu website. The models, experiments and inspirations presented in the MAST Manual have particular value for innovation, art and design educators interested in new methods and tools to develop teaching and learning approaches that involve a broad range of stakeholders of a much-needed novel pedagogy, both innovative in and critical of itself.